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The ultimate goal of developing pharmaceuticals using biotech methods is to enhance quality of life. However, developing more ef cacious con ventional pharmaceuticals is only one way of accomplishing this goal. For example, many medical conditions aren t responsive to pharmaceu ticals, but require surgical procedures. Furthermore, before a drug can be prescribed for a patient, a physician must arrive at the correct diagnosis an imperfect skill that requires years of training. Enhancing diag nosis is one of several areas in which biotech is being applied to the practice of clinical medicine. Other biotech applications in clinical medi cine are listed in Figure 1.5. Although the goal is to alleviate pain and suffering in patients, the fo cus of leading-edge medical research is at the molecular level. For exam ple, since the sequencing of the human genome, our understanding of diseases such as HIV, cystic brosis, and diabetes extends to DNA and the expression of certain genes. Specially bred and genetically modi ed mice and other laboratory animals and new computer techniques form the ba sis for many of the promising advances in cancer therapy. The goal of biotechnology applied to cancer therapy is to create more effective tissue speci c cancer therapies with fewer side effects, using technologies such as monoclonal antibodies. The value of duplicating or cloning antibodies or cells isn t limited to cancer therapy, but extends to tissues, organs, and entire organisms for or gan transplantation purposes. For example, pigs, primates, and other ani mals have been genetically engineered to lack antigens that trigger the rejection that can occur in xenotransplantation, which is the use of the

B (X(t), t)]

d~j (X{t))

QuickBooks allows you to create 11 different types of Items, as summarized in Table 10-1.

(8.68)

~B2 (X(t), t)

Focus Cancer Therapy Cloning Diagnosis Infectious Disease Gene Therapy Genetic Engineering Life Extension Xenotransplantation

Item Type Service Inventory Part Inventory Assembly (Premier and Enterprise editions only) Noninventory Part Fixed Asset (Pro, Premier, and Enterprise editions only) What to Use It For Services you charge for or purchase from others, such as labor, consulting hours, and professional fees Goods you purchase, track as inventory, and resell Assembled goods you build or purchase, track as inventory, and resell Goods you buy but don t track (such as of ce supplies) An asset you do not expect to convert to cash during one year of normal operations

j (X{t)) }dt + B (X(t), t)

Calling j (X{t)) a new stochastic variable,

yet) == j{X(t)),

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Miscellaneous labor, material, or part charges such as delivery charges, setup fees, and service charges Totals all Items above it on a form, up to the last subtotal; useful for applying a percentage discount or surcharge to many Items Useful to quickly enter a group of individual Items that you ve already set up as single Items on your list Subtracts a percentage or xed amount from a total or subtotal; do not use this Item type for an early payment discount Records a partial payment you received at the time of the sale; it reduces the amount owed on an invoice Calculates a single sales tax at a speci c rate that you pay to a single tax agency Calculates and individually tracks two or more Sales Tax Items that apply to the same sale; the customer sees only the total sales tax

Goals More effective tissue-speci c cancer therapies with fewer side effects Duplicate tissues and therapeutic bacteria and cells Enhance diagnosis by examining genes Improve treatment of diseases Identify and treat defective genes, enhance normal genes Perfect recombinant DNA, eugenics Determine and counteract molecular basis for aging and longevity Overcome tissue rejection in organ transplant patients

(8.69)

and assuming that there is an inverse transformation 9 (Y (t)) that changes Y (t) back into X(t), (8.70) X(t) = 9 (Y(t)), we see that

You can create Items easily in QuickBooks using Windows and prompts designed to ensure that you don t omit any useful information. The name or number of the new Item you create will appear on the drop-down list of Items when you are lling out a sales form or purchase order. The process differs slightly depending on whether you are creating Items for services or products.

cP f __

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